Synthesis, Characterization and Antibacterial Activity of Some Metal Complexes of Azo Guanosine and Adenosine Derivatives

Aljabar, Nahla A. A. and Abdulsattar, Ahmed (2017) Synthesis, Characterization and Antibacterial Activity of Some Metal Complexes of Azo Guanosine and Adenosine Derivatives. Eurasian Journal of Science and Engineering, 3 (1). pp. 99-108. ISSN 24145629

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Abstract

A series of new coordination complexes of Cu(II), Co(II), Ni(II) with the azo nucleosides derived from the coupling reaction of guanosine and adenosine with substituted phenyl diazonium salts have been prepared .These metal complexes were characterized by elemental analysis, IR, UV-Visible,Conductivity measurement and magnetic susceptibility. It was found that the azo compounds behavesas N,N’-Bidentate donor ligand forming chelates with 1:1 (metal: ligand) stoichiometry. The ligands and their metal complexes have been screened for their antibacterial activity against five species of pathogenic bacteria: Staphylococcus aureus, Streptococcus viridans, Proteus vulgaris, Pseudomonas aeruginosa and Escherichia coli using Disc diffusion method. The activity data had shown that the metal complexes to be more potent antibacterial than the parent azo ligands against one or more bacterial species suggesting that metalation increase the antibacterial activity of those compounds.

Item Type: Article
Uncontrolled Keywords: Azo Compounds, Metal Complex, Antibacterial
Subjects: Q Science > QD Chemistry
Divisions: Ishik Eurasian Journal of Science and Engineering > VOL 3, NO 1 (2017)
Depositing User: Depositor @ Ishik University
Date Deposited: 23 Apr 2018 20:45
Last Modified: 23 Apr 2018 20:45
URI: http://eprints.ishik.edu.iq/id/eprint/38

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